MULTIPLE SCLEROSIS
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MS
& DIABETES TORONTO,
March 20 /CNW/ via NewsEdge Corporation - A team of
researchers led by Hospital for Sick Children (HSC) senior scientist Michael
Dosch has determined that multiple sclerosis and type I (juvenile) diabetes
mellitus are far more closely linked than previously thought, including the role
cow milk protein plays as a risk factor in the development of both diseases for
people who are genetically susceptible. This research is published in recent
issues of The Journal of Immunology (April 1 and February 15, 2001). Multiple
sclerosis (MS) and type I diabetes mellitus are autoimmune disorders, where the
body's immune system attacks its own tissue. The diseases are entirely different
clinically, but have nearly identical ethnic and geographic distribution,
genetic similarities, and, as is now known, shared environmental risk factors. In a
collaboration between The Hospital For Sick Children, St. Michael's Hospital and
the Pittsburgh Children's Hospital, Dr. "Much to our
surprise, we found that immunologically, type I diabetes and multiple sclerosis
are almost the same - in a test tube you can barely tell the two diseases
apart," said Dr. Dosch, the study's In diabetes and
MS, there is a long, drawn-out period of silent disease years before the
appearance of symptoms and diagnosis of the disease. In diabetes, it is this
"pre-diabetes" phase that is targeted by interventions to stop the
development of the full-blown disease. Similar efforts are planned for
individuals at high risk for "We are
planning a large international study with centres in Canada and the US to test
the possibility of interventions during the pre-MS phase," added Dr. Dosch.
One of the major
environmental risk factors for diabetes is exposure to cow milk protein. Based
on the role of cow milk protein as a risk factor in the development of type I
diabetes, an international global "The
similarities found between MS and type I diabetes will open new avenues of
research. Our next focus will be to study MS family members for signs of early
MS," said Dr. Paul O'Connor, head of the MS clinic at St. Michael's
Hospital, a co-author of the study and Associate Professor of Neurology at U of
T. Other
collaborators on this research were: Shawn Winer, Igor Astsaturov, Roy K.
Cheung, Lakshman Gunaratnam, Denise D. Wood and Funding for this
research was provided by the Canadian Institutes of Health Research, the
Juvenile Diabetes Foundation, the Canadian Diabetes Association, the US National
Institutes of Health and the For further
information: please contact: Laura Greer, Public Affairs, The Hospital for Sick
Children, (416) 813-5046, Copyright ©
2001, Individual.com, Inc.TM Jean
Administrator
Member # 5 04-11-2001 11:59 PM
Diabetes
And Multiple Sclerosis Patients Share Common Autoantigens WESTPORT, CT
(Reuters Health) Mar 05 - Autoreactive T cells from both diabetic patients and
multiple sclerosis (MS) patients target autoantigens in islet cells and the
central nervous system, according to a report in the February 15th Journal of
Immunology. As the authors point out, "what (usually) protects diabetics
from MS, and MS patients from diabetes...could have therapeutic
ramifications." Dr. H.-Michael
Dosch from The Hospital for Sick Children in Toronto, Ontario, Canada and
colleagues analyzed T cell autoreactivity in 38 patients with stable or
relapsing MS, 54 newly diagnosed children with diabetes and 105 of their
first-degree relatives, and 34 healthy controls. Besides
recognizing myelin basic protein epitopes, T cells from MS patients frequently
targeted self-antigens associated with autoimmune diabetes, the authors report,
a phenomenon rarely shown by T cells from healthy controls. Similarly, T
cells from about two-thirds of diabetes patients and their first-degree
relatives at high risk of developing diabetes showed proliferative responses to
at least one MS-associated antigen, the report indicates. Low-risk relatives
were less likely to have such autoreactive T cells. "Thus
autoimmunity in diabetes and MS targets a similar set of self-proteins, with
neither disease nor tissue selectivity, although epitopes and T cell
specificities appear to differ," the researchers note. "Our work
implies that there is a lengthy, clinically silent pre-MS phase analogous to
prediabetes," Dr. Dosch told Reuters Health. "That's good news: there
is strong consensus that we will stop diabetes within a reasonable time frame
through intervention therapies that are targeted to early prediabetes. We hope
(and have some reason) that the same will turn out to be true for MS, where
treatments are rather ineffective." "We are
preparing for a major, multi-center initiative with several US centers to seek
out evidence for pre-MS," Dr. Dosch said. J Immunol
2001;166:2831-2841. Disclaimer: This material is provided as general medical information only and may not include all side effects or details relevant to a particular individual's treatment. Answers are not intended as advice for individual patients; please contact your own physician/neurologist for specific recommendations. |